One of the best practices, according to the Well Architected Framework (WAF) guidelines, is zonal deployment. By adopting this recommendation, you can now design your solutions to utilize zonal VMs, ensuring the isolation of your VMs from potential failures in other zones. With this, you can expect enhanced resiliency in your workload by avoiding downtime and business interruptions.
To learn more adopting the best practice, visit Reliability recommendations - Azure Advisor | Microsoft Learn.