.NET Core 2.2 is now available in all public regions and sovereign cloud regions for Azure App Service on Windows. This also includes customers using App Service environments.
.NET Core 2.2 brings customers major improvements, including 64-bit support and the ability to run .NET Core 2.2 applications in-process for improved throughput and performance. You can read about all of the new .NET Core 2.2 features and benefits on the ASP.NET blog.